黄琳

主任药师、副教授、学硕导师，药学院专硕导师在岗

研究领域：药物基因组学、治疗药物监测和药物个体化应用研究

电话：（010）88325750

电子邮箱：huanglin@pkuph.edu.cn

教育背景

华中科技大学同济医学院医学博士（2008）

华中科技大学同济医学院医学学士（2004）

工作经历

2022.08至今            北京大学人民医院药学部，党支部书记

2020.08至今            北京大学人民医院药剂科，副教授

2018.12至今            北京大学人民医院药剂科，学科助理/临床药学组长

2017.10-2018.09         美国匹兹堡大学药学院，访问学者

2017.08至今            北京大学人民医院药剂科，主任药师

2012.08-2017.07         北京大学人民医院药剂科，副主任药师

2008.08-2012.07         北京大学人民医院药剂科，主管药师

社会兼职

中国研究型医院学会药物经济学专委会常务委员

中国研究型医院学会儿科学专委会委员

中国医药教育协会老年药学专委会委员

中国心胸血管麻醉学会心血管药学分会委员

北京大学治疗药物监测和临床毒理中心专家委员会副主任委员

北京医学会临床药学分会委员

北京药学会临床研究与转化专业委员会委员

北京药理学会合理用药与健康促进分会委员

北京医学会鉴定专家

《药物不良反应杂志》通讯编委

代表性论文

 1.Xu Hao*, Yuanyuan Li*, Ying Zhang, Jialu Bian, Jinxia Zhao, Yinyu Zhao, Lei Hua, Xingxian Luo, Changqing Yang, Yufei Feng,

Lin Huang#. Individualized treatment with voriconazole in the Chinese population: inflammation level as a novel marker for dose optimization [J].

British Journal of Clinical Pharmacology, 2023, Br J Clin Pharmacol. 2023 Sep 27. doi: 10.1111/bcp.15916. Online ahead of print.

2.Shi-yu He, Jin-xia Zhao, Jia-lu Bian, Yin-yu Zhao, Yuan-yuan Li, Nan Guo, Lei Hu, Bo-yu Liu, Qian-hang Shao, Huan He, Lin Huang#,

and Qian Jiang#.Population Pharmacokinetics and Pharmacogenetics Analyses of Dasatinib in Chinese Patients with Chronic Myeloid Leukemia [J].

Pharmaceutical Research, 2023 Sep 19. doi: 10.1007/s11095-023-03603-z. Online ahead of print.

3.Yuanyuan Li*, Ying Zhang*, Jinxia Zhao, Jialu Bian, Yinyu Zhao, Xu Hao, Boyu Liu, Lei Hu, Fang Liu, Changqing Yang, Yufei Feng#,

Lin Huang#. Combined Impact of Hypoalbuminemia and Pharmacogenomic Variants on Voriconazole Trough Concentration：data from

a real-life clinical setting in the Chinese population [J]. Journal of Chemotherapy, 2023 Aug 20;1-11.

doi: 10.1080/1120009X.2023.2247208. Online ahead of print.

4.Shiyu He*; Qianhang Shao*; Jialu Bian; Jinxia Zhao; Yinyu Zhao; Lei Hu; Boyu Liu; Huan He; Lin Huang#; Qian Jiang#. Population Pharmacokinetics

and Pharmacogenetics Analyses of Imatinib in Chinese Patients with Chronic Myeloid Leukemia in a Real-World Situation [J].

Cancer Chemotherapy and Pharmacology, 2023 Nov; 92(5):399-410.

5.Jialu Bian, Jinxia Zhao, Yinyu Zhao, Xu Hao, Shiyu He, Yuanyuan Li, Lin Huang#. Impact of Individual Factors on DNA Methylation of Drug

Metabolism Genes: A Systematic Review [J]. Environmental and Molecular Mutagenesis, 2023 Aug; 64(7): 401-415.

6.Jinxia Zhao, Jialu Bian, Yinyu Zhao, Yuanyuan Li, Boyu Liu, Xu Hao, Shiyu He, Lin Huang#. Pharmacogenetics Aspects of Drug Metabolizing Enzymes

and Transporters in Pediatric Medicine: Study Progress, Clinical Practice and Future Perspective [J]. Pediatric Drugs, 2023 May; 25(3): 301-319.

7.Boyu Liu, Na Geng, Haiyan Zhao, Yiran Tao, Lei Hu, Lin Huang#, Yufei Feng#. Development of UHPLC method for simultaneous determination of

tacrolimus and sirolimus in human whole blood and comparisons with two immunoassays[J]. Biomedical Chromatography, 2023 Feb;37(2): e5538.

8.Xu Hao, Yuanyuan Li, Jialu Bian, Ying Zhang, Shiyu He, Feng Yu, Yufei Feng#, Lin Huang#. Impact of DNA methylation on ADME gene expression,

drug disposition, and efficacy[J]. Drug Metabolism Reviews, 2022, 54(2):194-206.

9.Ying Zhang, Xu Hao, Kelu Hou, Lei Hu, Jingyuan Shang, ShiYu He, Changqing Yang, Lin Huang# and Yufei Feng#. Impact of cytochrome P450 2C19

polymorphisms on the clinical efficacy and safety of voriconazole: an update systematic review and meta-analysis[J].

Pharmacogenetics and Genomics, 2022, 32(7): 257-267.

10.Shiyu He, Jialu Bian, Qianhang Shao, Ying Zhang, Xu Hao, Xingxian Luo, Yufei Feng^#, Lin Huang^#. Therapeutic Drug Monitoring and Individualized

Medicine of Dasatinib: Focus on Clinical Pharmacokinetics and Pharmacodynamics. [J]. Frontiers in Pharmacology, 2021,12: 797881.

11.Chunyan Zhang, Jing Lei, Yi Liu, Yu Wang, Lin Huang^# and Yufei Feng^#. Therapeutic Drug Monitoring and Pharmacogenetic Testing in Northern China.

[J]. Frontiers in Pharmacology, 2021,12: 754380.

12.Ying Zhang, Kelu Hou, Fang Liu, Xingxian Luo, ShiYu He, Lei Hu, Changqing Yang, Lin Huang^# and Yufei Feng^#. The influence of CYP2C19

polymorphisms on voriconazole trough concentrations: a systematic review and meta-analysis [J]. Mycoses, 2021;64(8):860-873.

13.Huihui Fang, Xiaojuan Wang , Kelu Hou, Zhiying Yu, Lei Hu, Shuai Shao, Guijie Zhang, Yufei Feng^# and Lin Huang^#. Association between

valproic acid and CYP2C9 gene polymorphism in patients with epilepsy: a meta-analysis [J]. Annals of Translational Medicine, 2021.

14.Xingxian Luo, Taifeng Li, Lei Hu, Silu Liu, Haiyan Zhao, Jiaqi Zhang, Yufei Feng^# and Lin Huang^#. Differential effects of C-reactive

protein levels on voriconazole metbolism at three age groups in allogeneic hematopoietic cell transplant recipients. [J].

Journal of Chemotherapy, 2021, 33(2): 95-105.

15.Xingxian Luo, Xuecai Xue, Taifeng Li, Yin Zhang, Lin Huang^# and Gang Cheng^#. Differential impacts of azole antifungal drugs on the

pharmacokinetic profiles of dasatinib in rats by LC-MS-MS [J]. Current Drug Metabolism, 2020, 21(13):1022-1030.

16.Kelu Hou, Zhiying Yu, Yueping Jia, Huihui Fang, Shuai Shao, Lin Huang^# and Yufei Feng^#. Efficacy and Safety of Ibrutinib in Diffuse Large

B-Cell Lymphoma: A Single-Arm Meta-Analysis [J]. Critical Reviews in Oncology/Hematology, 2020 Aug; 152: 103010. 

17.Shuai Shao, Lei Hu, ZaiGang Han, Kelu Hou, Huihui Fang, Guijie Zhang, Yufei Feng^#, Lin Huang^#. The effect of ABCB1 polymorphism on sirolimus

in renal transplant recipients: a meta-analysis [J]. Translational Andrology and Urology, 2020, 9(2): 673-683.

18.Xingxian Luo，Taifeng Li，Ze Yu，Xuecai Xue, Haiyan Zhao, Na Li, Liping Ma, Jing liu, Changqing Yang, Lin Huang^#, Wangyu Feng^#. The impact

of azole antifungal drugs on imatinib metabolism in human liver microsomes[J]. Xenobiotic.2019; 49(7): 753-761.

19.Li TF, Hu L, Ma XL, Huang L, Liu XM, Luo XX, Feng WY, Wu CF. Population pharmacokinetics of cyclosporine in Chinese children receiving

hematopoietic stem cell transplantation. Acta Pharmacol Sin. 2019 Dec; 40(12):1603-1610.

20.Iasella CJ, Kreider MS, Huang L, Coons JC, Stevenson JM. Effect of Selective Serotonin Reuptake Inhibitors on Cardiovascular Outcomes

After Percutaneous Coronary Intervention: A Retrospective Cohort Study. Clin Drug Investig. 2019; 39(6): 543-551.

荣誉奖励

2016-2017年度中华医学会临床药学分会优秀临床药师

2013-2014年度北京药学会临床药学之星

2013-2014、2016-2017、2019-2020、2020-2021年度北京大学人民医院优秀共产党员